| Plantar wart |
|---|
| Classification and external resources |
A plantar wart. Striae (fingerprints) go around the lesion. |
| ICD-10 | B07 |
|---|
| ICD-9 | 078.12 |
|---|
A plantar wart (also known as "Verruca plantaris"[1]:405) is a wart caused by the human papillomavirus occurring on the sole or toes of the foot. (HPV infections in other locations are not plantar; see human papillomavirus.) Plantar warts are usually self-limiting, but treatment is generally recommended to lessen symptoms (which may include pain), decrease duration, and reduce transmission.[2]
Contents [hide] - 1 Infection and development
- 2 Diagnosis
- 3 Prevention
- 4 Treatment
- 4.1 Medications
- 4.2 Surgery
- 4.3 Other
- 4.4 Relative effectiveness
- 5 References
- 6 External links
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[edit]Infection and development
It is estimated that 7–10% of the US population is infected. Infection typically occurs from moist walking surfaces such as showers or swimming pools. The virus can survive many months without a host, making it highly contagious.[2][3]
Plantar warts are benign epithelial tumors caused by infection by human papilloma virus types 1, 2, 4, or 63[3]. These types are classified as clinical (visible symptoms). The virus attacks the skin through direct contact, entering through possibly tiny cuts and abrasions in the stratum corneum (outermost layer of skin). After infection, warts may not become visible for several weeks or months. Because of pressure on the sole of the foot or finger, the wart is pushed inward and a layer of hard skin may form over the wart. A plantar wart can be painful if left untreated.[2][4]
Warts may spread through autoinoculation, by infecting nearby skin or by infecting walking surfaces. They may fuse or develop into clusters called mosaic warts.[3]
[edit]Diagnosis
A plantar wart is a small lesion that appears on the sole of the foot and typically resembles a cauliflower, with tiny black petechiae (tinyhemorrhages under the skin) in the center. Pinpoint bleeding may occur when these are scratched, and they may be painful when standing or walking.
Plantar warts are often similar to calluses or corns, but can be differentiated by close observation of skin striations. Feet are covered in skin striae, which are akin to fingerprints on the feet. Skin striae go around plantar warts; if the lesion is not a plantar wart, the cells' DNA is not altered and the striations continue across the top layer of the skin. Plantar warts tend to be painful on application of pressure from either side of the lesion rather than direct pressure, unlike calluses (which tend to be painful on direct pressure instead).
[edit]Prevention
Because plantar warts are spread by contact with moist walking surfaces, they can be prevented by not walking barefoot in public areas such as showers or communal changing rooms (wearing flip flops or sandals helps), not sharing shoes and socks, and avoiding direct contact with warts on other parts of the body or on other people. Humans build immunity with age, so infection is less common among adults than children.[4]
As warts are contagious, precautions should be taken to avoid spreading them. The British National Health Service recommends that children with warts:
- cover them with an adhesive bandage while swimming,
- wear flip-flops when using communal showers,
- and should not share towels.[5]
[edit]Treatment
| First-line therapy | Over the counter salicylic acid |
| Second-line therapy | Cryosurgery, intralesional immunotherapy, or pulsed dye laser therapy |
| Third-line therapy | Bleomycin, surgical excision |
Once a person is infected, there is no evidence that any treatment eliminates HPV infection or decreases infectivity, and warts may recur after treatment because of activation of latent virus present in healthy skin adjacent to the lesion. There is currently no vaccine for these types of the virus[dubious – discuss][citation needed]. However, treatments are sometimes effective at addressing symptoms and causing remission(inactivity) of the virus.[3]
Some treatments that have been found to be effective include:[6]
[edit]Medications
Keratolytic chemicals The treatment of warts by keratolysis involves the peeling away of dead surface skin cells with trichloroacetic acid or salicylic acid, which can be prescribed by a physician in a higher concentration than that found in over-the-counter products.
Immunotherapy Intralesional injection of antigens (mumps, candida or trichophytin antigens USP) is a new wart treatment which may trigger a host immune response to the wart virus, resulting in wart resolution. Distant, non-injected warts may also disappear.
Chemotherapy Topical application of dilute glutaraldehyde (a virucidal chemical, used for cold sterilization of surgical instruments) is an older effective wart treatment. More modern chemotherapy agents, like 5-fluoro-uracil, are also effective topically or injected intralesionally. Retinoids, systemically (e.g. isotretinoin) or topically (tretinoin cream) may be effective.
[edit]Surgery
A ~7mm plantar wart surgically removed from patient's footsole after other treatments failed.
A common surgical method involves cryosurgery using liquid nitrogen; this method produces a blister under the wart. Electrodesiccation and surgical excision produce scarring. If the wart recurs, the patient has a permanent scar along with the wart. Laser surgery may be effective. Especially effective is the use of the 585 nm pulsed dye laser. It is the most effective treatment of all and does not leave scars, but it is generally a last resort treatment, as it is expensive and painful, and multiple laser treatments are required (generally 4-6 treatments repeated once a month until the wart disappears). Cauterization may be effective as a prolonged treatment. As a short-term treatment, cauterization of the base with anaesthetic can be effective, but this method risks scars or keloids. Subsequent surgical removal is unnecessary, and risks keloids and recurrence in the operative scar.[7]
[edit]Other
Suffocation of the surrounding skin with plastic is anecdotally effective, akin to the "duct tape" method. A layer of plastic wrap is cut slightly larger than the surface area of the wart(s), and then affixed firmly with a bandage. Care must be taken to ensure the skin does not breathe for long periods between fresh dressings, and effective results should be noticeable within 2 weeks, or else be discontinued. Despite the excess moisture of sweat, the lack of oxygen speeds the degeneration of the wart and surrounding skin; especially in combination with other treatments that gradually expose the root, such as salicylic acid.
[edit]Relative effectiveness
A 2006 review of the effects of different local treatments for cutaneous, non-genital warts in healthy people concluded: [8]
- overall there is a lack of evidence (many trials were excluded because of poor methodology and reporting).
- the average cure rate using a placebo was 27% after an average period of 15 weeks.
- the best treatments are those containing salicylic acid. They are clearly better than placebo.
- there is little clinical trial data for the absolute efficacy of cryotherapy
- two trials comparing salicylic acid and cryotherapy showed no significant difference in efficacy.
- one trial comparing cryotherapy and duct tape occlusion therapy showed no significant difference in efficacy.
- evidence for the efficacy of the remaining treatments was limited.
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