[www.keralites.net] Scientists discover protein that may help prevent cataract

 

Scientists discover protein that may help prevent cataract

Washington: Scientists have taken a step closer to prevent cataract from striking by finding out the activation mechanism of the protective protein that saves human eyes from falling prey to disease.

The lens of the human eye is made up of a highly concentrated protein solution that imparts the eye its high refractive power. Yet, despite this high protein content the ocular lens must remain clear and transparent.

To this end ocular lens cells have developed a remarkable strategy: They have thrown overboard the complex machinery present in all other cells of the human body for building up and breaking down proteins. Instead, lens proteins are created only once in a lifetime - during embryonic development.

In 2009, Johannes Buchner, professor for biotechnology at the Technische Universitaet Muenchen collaborated with Sevil Weinkauf, professor for electron microscopy at the Technische Universitaet Muenchen, and helped the first part of the aB-crystallin puzzle fall into place.

The team successfully deciphered the molecular structure of the most important form of this versatile protein - a molecule comprising 24 subunits. Under normal conditions, i.e. when the cell is not exposed to stress, this complex is the most common variant.

However, it is merely an idle form that contributes little to the prevention of clumping in other proteins. It was clear that there must be another molecular switch that triggers the protective protein.

It is this trigger mechanism that the team headed by Buchner and Weinkauf uncovered now. When a cell is exposed to stress, for instance when subjected to heat, phosphate groups are attached to a specific region of the protein.

The negative charges of these phosphates break the links between the subunits and the large complexes consequently disintegrate into numerous smaller ones of only six or twelve subunits each.

As a result of this breakup, the regions at the ends of the complexes become more flexible allowing the molecules to dock up with different partners, thereby preventing them from clumping - the protective protein is now active.

The study has been published in Proceedings of the National Academy of Sciences.

http://zeenews.india.com/news/health/diseases/scientists-discover-protein-that-may-help-prevent-cataract_24671.html

Ravi
 

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Re: [www.keralites.net] Malala Yousafzai amazing answer on The Daily Show with Jon Stew

 

The incidents in Delhi, America, etc are by mentally sick individuals. The
only support they get will be from their close relatives. The law of the
land prosecutes and punishes these people. What was happening in Pakistan
was a strong terrorist organisation(Taliban) wanted to impose their ideas
of good behaviour and culture on the vast majority . The majority of people
and the Govt are scared to fight back the Taliban . It requires enormous
guts and determination for a small girl to fight this great evil. She can
encourage wide spread condemnation of the Taliban among Muslims world wide.
Muslims in India also should condemn the Taliban.




Regards,
Allen Peter



From: PSK <pskoya2004@yahoo.com>
To: Keralites@yahoogroups.com
Date: 10/24/2013 09:48 PM
Subject: Re: [www.keralites.net] Malala Yousafzai amazing answer on The
Daily Show with Jon Stew
Sent by: Keralites@yahoogroups.com






It is jihad against some community. The real JIHAD. There are many fools
believing that nobody knew it.



There is a case in Delhi that some boys poured acid on a 16 year old girl's
face and she suferred badly. Nobody is cared about it, the attrocities
against wemon all over the world.

In america also there are many cases. Shooting themselves etc. If you go
inside America and Britain, ho! you can not imagin.

And they are the BIG BOSS'.

Best Regards
PS. Koya

From: sajad <sajadklm@gmail.com>
To: Keralites@yahoogroups.com
Sent: Wednesday, October 23, 2013 4:04 PM
Subject: Re: [www.keralites.net] Malala Yousafzai amazing answer on The
Daily Show with Jon Stew

Malala is a conspiracy of USA, UK & Pankistan Army. I wonder why Mr. Obama
took more than half an hour to talk about malala case in UN meeting.
Infacts of malala case giving me a Ironical feelings and The world against
islamism instead of thousands of poor kids killed in Afganistan, Syria
Falasteen by so-called US, UK & Israyel.

Sajjad......
On Thu, Oct 10, 2013 at 4:48 AM, Aniyan <jacobthomas_aniyankunju@yahoo.com>
wrote:


Malala Yousafzai giving an emotional answer about how she would treat
a member of the Taliban if he came to her house.


Taken from The Daily Show dated 2013.10.08.

[The Girl truly deserves a Nobel Prize]


https://youtube.googleapis.com/v/WQy5FEugUFQ

www.keralites.net


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@sajju........!!

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[www.keralites.net] Loving someone

 

Loving someone; Loving someone who doesn't love you Is like waiting a ship in the airport   (Meaning will never come).

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[www.keralites.net] Grandmothers Posing with their Signature Dish by twisted Sifter

 

Grandmothers Posing with their Signature Dish

Posted:24 Oct 2013 10:50 AM PDT

Italian artistis a commercial photographer (featured previouslyhereandhere) whose human-interest photo series have garnered critical acclaim.

During a recent 18-month couch surfing trip around the world, Galimberti pursued a number of personal photo projects includingDelicatessen with love, where he asked grandmothers to prepare their signature dishes. In a side by side series, Galimberti took portraits of the women with the ingredients used to cook the meal on one side and the finished dish on the other.

Galimberti took the project a step further, collecting the recipes for each meal, which you can find on hisofficial site. Below is a small selection from this heartwarming series. To see all 44 grandmothers, dishes and recipesclick here.

1. Ayten Okgu , 76 years old - Istanbul, Turkey
Karniyarik (stuffed aubergines with meat and vegetables)

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2. Pan Guang Mei, 62 years old Chongqing, China
Hui Guo Rou (twice-cooked pork with vegetables)

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3. Bisrat Melake, 60 years old Addis Ababa, Ethiopia
Enjera with churry and vegetables

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4. Marisa Batini, 80 years old Castiglion Fiorentino, Italy
Swiss chard and ricotta Ravioli with meat sauce

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5. Thilaga Vadhi, 55 years old Kuala Lumpur, Malaysia
Nasi Lemak (coconut rice with vegetables and fried dried anchovies)

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6. Natalie Bakradze, 60 years old - Tblisi, Georgia
Khinkali (pork and beef dumplings)

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7. Serette Charles, 63 years old Saint-Jean du Sud, Haiti
Lambi in creole sauce

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8. Eti Rumiati, 63 years old Jakarta, Indonesia
Soto Betawi (beef soup with coconut and vegetables)

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9. Fifi Makhmer, 62 years old - Cairo, Egypt
Kuoshry (pasta, rice and legumes pie)

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10. Boonlom Thongpor, 69 years old Bangkok, Thailand
Kai Yat Sai (stuffed omelette)

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11. Julia Enaigua, 71 years old La Paz, Bolivia
Queso Humacha (vegetables and fresh cheese soup)

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12. Normita Sambu Arap, 65 years old Oltepessi (masaai mara) Kenya
Mboga and orgali (white corn polenta with vegetables and goat)

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13. Itala Revello Rosas, 77 years old Lima, Peru
Corvina fish ceviche

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14. Ivonete Tortoretti Correa, 64 years old Sao Paulo, Brazil
Rice, Farofa, beans and meat

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15. Regina Lifumbo, 53 years old Mchinji, Malawi
Finkubala (Caterpillar in tomato sauce)

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16. Eija Bankach, 62 years old - Massa, Morocco
Chicken Tajine

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17. Fernanda De Guia, 71 years old – Manila, Philippines
Sinigang (tamarind soup with pork and vegetables)

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18. Isolina Perez De Vargas, 83 years old Mendoza, Argentina
Asado Criollo (mixed meats barbecue)

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