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Thursday, 6 December 2018

[www.keralites.net] Neem could help kill cancer Cells

http://post.jagran.com/Neem-could-help-destroy-cancer-cells…
'Neem' could help kill cancer cells
Washington: Scientists have discovered that Neem, used for centuries by Indians to treat inflammation, fever and malaria, could help kill cancer cells.
Cancer cells typically avoid death by hijacking molecular chaperones that guide and protect the proteins that ensure normal cellular function and then tricking them into helping mutated versions of those proteins stay alive, said Dr Ahmed Chadli, researcher in the Molecular Chaperone Programme at the
Georgia Regents University Cancer Center.
Drug development has focused on the chaperone Hsp90 - heat shock protein 90 because it plays a key role in assisting mutated proteins, making it an attractive cancer drug target.
However, the clinical efficacy of Hsp90 inhibitors has been disappointing, according to the study published in the Journal of Biological Chemistry.
Most current small molecules targeting Hsp90 have inadvertently resulted in the expression of proteins that protect cancer cells from programmed cell death and compromise the Hsp90 inhibitors in the clinic.
In this study, however, Chaitanya Patwardhan, a graduate student in Chadli's lab, found that gedunin, compound from the Indian plant 'neem', attacks a co-chaperone, or helper protein, of Hsp90 called p23. "This compound binds directly to p23, leading to inactivation of the Hsp90 machine without production of anti-apoptotic proteins - thus killing cancer cells," Chadli said in a statement.
"The idea here is that this will open a door for new ways of targeting Hsp90 by targeting its helper proteins, which may be used in combination with established Hsp90 inhibitors that are ongoing clinical trials. "In the future, this research could have applications in drug development for hormone-dependent cancers, including breast, prostate and endometrial cancers," said Chadli.
"One of the major areas of scientific emphasis of the GRU Cancer Center is to develop therapeutic approaches to cancer targeting specific molecules within the cancer cell, including chaperones," said Dr Samir N Khleif, Director of the GRU Cancer Center.
"This finding is an important piece of the puzzle, bringing us closer to our goal of helping patients with cancer," said Khleif.

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[www.keralites.net] Amazing Benefits Of Water

13 Amazing Benefits ....Water is one of the most imperative substances that we need to sustain on this earth. According to experts, 7 to 8 glasses of water is essential for each and every human being. Though most of the people prefer consuming cold or normal water, researches have shown that drinking hot or warm water has some exclusive benefits in your health. It has quite a few positive impacts on your skin and hair. Let us discuss about those beneficial aspects of drinking hot water here:

Benefits of Drinking Hot Water for Health:

Hot water is a natural body regulator. If you kick start your day by drinking a glass of pure warm water, you can easily step towards a healthy life. Have a glimpse of the health benefits that hot water could offer:
1. The first and foremost advantage of drinking hot water is ultimate detoxification of your body. Whether you are suffering from indigestion or trying to get rid of impurities present in your body, developing a habit of consuming hot water early in the morning and late at night every day can help you immensely in your way. When you drink hot water, the body temperature goes up and start sweating, which can flush the toxic materials out of your internal system and cleanse it properly. For optimal results, squeeze a lemon and add a few drops of honey to it.
2. Scarcity of water within your body can result in acute chronic problem of constipation. As the stool gets accumulated inside your intestine, the movement of bowel becomes slower. It is always recommended that you consume a glassful of hot or warm water every morning when your stomach is empty. It decomposes the foodstuffs and makes the movement of the particles smooth and less painful through the intestine.
3. Hot water is particularly beneficial for digestion. Studies have revealed that drinking cold water right after meal can harden the oil present in the consumed foods. It creates a fat deposit on the inner wall of your intestine, which eventually results into intestinal cancer. However, if you replace the glass full of cold water with one having hot water, you can avoid this problem and accelerate your digestion to a great extent.
4. Are you dying to lose a few pounds? Hot water can help you in that. It promotes your metabolism and breaks down the adipose tissues lying under the skin, especially when taken with lemon and honey. Consequently, you will get rid of excess body weight. Hot water for weight loss is an excellent solution.
[ Read: Lemon Water ]
5. Drinking hot water is an excellent natural remedy for cold, cough and sore throat. It dissolves thick cough or phlegm and eliminates that easily from your respiratory tract so that you can get relief from sore throat. Hot water also helps in clearing the nasal congestion.
6. Another important benefit of hot water intake is enhanced circulation of blood. As mentioned earlier, it burns out the body fat. At the same time, it also breaks down the deposits present in the nervous system.
7. Hot water can also aid in menstrual cramps. Girls can add some carom seeds to it and drink the concoction during their periods. The heat of the water has a calming and soothing effect on the abdominal muscles, which eventually cure the cramps and spasms.
Benefits of Drinking Hot Water for Skin:

Hot or warm water is extremely beneficial for your skin. Instead of using lots of expensive cosmetics, you can just rely on this simple natural remedy and get a healthy glowing skin. Explore the skin benefits of drinking hot water in the following section:
8. First of all, you can prevent premature ageing and hold a dazzling and youthful skin for long by drinking a glass of hot water daily. It flushes out the toxins from your body and repairs the skin cells that are affected by harmful free radicals. The elasticity of your skin increases with hot water intake. As a result, your damaged skin becomes tones, wrinkle-free and beautiful.
[ Read: Cardamom Seed Benefits ]
9. By consuming hot water in a regular manner, you can keep the body hydrated and warm. It is really useful for dry and flaky skin. Furthermore, it is also necessary for maintaining a healthy skin as it improves blood circulation throughout your body and gives a rosy complexion.
10. Keep your skin free from acne, pimple and other skin disorders by drinking hot water daily. It deep cleanses your body and eliminates the root causes of those infections.
Benefits of Drinking Hot Water for Hair:

Each of the hair strands comprises almost 25% of water. Therefore, proper intake of water is crucial to get strong and healthy tresses. Know more about how hot water can help you in this purpose:
11. Hot or warm water works as a great source of energy for your hair cells. It promotes their regular activities and accelerates the growth of your tresses.
12. It keeps your scalp hydrated and helps fight against dry scalp or dandruff.
[ Read: Cinnamon Powder Benefits ]
13. Drinking hot water is also good for getting supple and gleaming hair. It energizes the nerve endings present in your hair roots and makes them active. This is beneficial for getting back the natural vitality of your hair and keeping it healthy.
So start your day with a glass of hot water and experience the miracle! Don't forget to leave us a comment.
Benefits Of Hot Water For Skin, Hair And HEALTH

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Wednesday, 5 December 2018

[www.keralites.net] Why Grapes Are Good

5 Solid Reasons Why Grapes Are Good For You
Written by: Tim Bura

Grapes are very popular due to their tart flavor, crisp texture, refreshing moisture and attractive color. The good news is that these fruits are packed with essential nutrients and are almost medicinal in nature due to the various health benefits they provide.

In this article we will look at why grapes are good for you and why you should be consuming a lot more of this delicious fruit.

1.) Grapes Are Good Sources Of Vitamins
There are various types of grapes available, varying in color and taste. There are black, purple, green as well as pink colored grapes in existence.

Irrespective of the type of grape you eat, you can rest assured that they are choke full of essential vitamins like Vitamin A, Vitamin C, Vitamin B6, Vitamin B and Folate. A four Oz serving of grapes can contain anywhere close to 20-25% of your daily required serving of Vitamin C.

2.) Grapes Are Rich In Essential Minerals
One reason why grapes are good for your health and should be a part of your daily diet is the various minerals your body can derive from these fruits. The most significant minerals present in grapes are Manganese and Potassium.

These minerals are essential to maintain good blood health, reduce the risk of hypertension, and improve immunity.

Some components present in red grapes are known to help ease depression.

Other minerals found in grapes are Copper, Zinc, Calcium, Phosphorous, Iron and Selenium.

3.) Grapes Are Good For Your Heart Health
Grapes are rich in antioxidants due to the presence of phytonutrients called polyphenols.

These antioxidants bind with the "free radicals" present in your body and reduce the risk of plague formation on the arteries, thus improving your heart's health.

Grapes also help in the generation of nitric oxide in the body. This compound helps improve heart health by reducing blood clots, platelet aggregation and oxidation of LDL (which causes plagues on the arteries).

Resveratrol, a compound found in grape skin and seeds, keeps the heart muscles flexible and healthy. The reason why 'red wines' have gained popularity is because of their high concentration of Resveratrol.

The French who eat a high fat diet have been found to have low heart disease stats, a phenomenon known as the French Paradox, which is largely owning to their consumption of red wine and grapes.

Grapes also contain a glucose based compound called Saponin (activated upon fermentation) which helps reduce the absorption of cholesterol and settles down inflammation path ways thus reducing the risk of heart diseases.

So grapes are definitely good for the heart.

4.) Grapes Help Prevent Cancer Formation
Thanks to the presence of antioxidant compounds in grapes, it helps bind free radicals in the body. These free radicals or oxidants are responsible for instigating cancer formation in various organs of the body.

It has been studied that drinking red wine can reduce the risk of lung cancer by 13%, owing to high concentration of antioxidants like resveratrol. You can get the same benefit from eating purple grapes on daily basis, if you don't want to drink red wine.

Drinking a couple of glasses of grape juice (made from purple grapes, especially the Concord) helps reduce the risk of colon cancer and breast cancer. The various compounds present in grapes helps reduce inflammation in the body and provide beneficial anti-oxidative effect.

5.) Grapes Aid The Digestive System Due To Their Anti-Microbial Properties
It has been found the grapes have several anti-microbial properties but they are not harmful to the beneficial bacteria in the stomach. Tests have shown that grape extracts inhibited the growth of 14 different types of harmful bacteria commonly found in human intestine and stomach including E coli, Salmonella and H. pylori (which causes stomach ulcers).

Grapes are good fact sheet

Grapes not only make for a tasty snack but are very beneficial to the human body. The various benefits listed in this article should give you an insight into the ample advantages of eating this fruit. You can consume grapes as fresh fruit, in the form of red wine, grape juice or even as a dry fruit, to accrue its benefits.