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Saturday, 3 November 2018

[www.keralites.net] Role of insulin in diabetes and obesity-Dr. Jagannath Dixit MBBS MD. - Very good article.

Role of insulin in diabetes and obesity-Dr. Jagannath Dixit MBBS MD.

Professor and Head of Community Medicine Department at Government Medical College, Latur, Maharashtra

dedicated and devoted medical teacher, with more than 28 years of experience of teaching in medical colleges

Insulin is a chemical substance scientifically termed as hormone from a gland called pancreas in your body. It is secreted in two different ways. One is called as baseline secretion; in which pancreas secrete 18 to 32 units of insulin throughout the day. This secretion cannot be stopped as it is essential for survival. The other method of insulin secretion depends on food intake. Every time you eat insulin is secreted. It is expected that out of your total insulin requirement, half should come as baseline secretion and half from secretion in response to eating episodes. Whatever you eat, insulin is secreted. It is documented that whether you take less food or more a similar amount of insulin is secreted every time. This we label as individual 'measure' of insulin which is person specific. It can be 2 units for one and 12 units for the other. Once insulin is secreted or your measure gets emptied, it takes 55 minutes to refill it. Hence if you eat up to 55 minutes, insulin will be secreted only once. If you continue eating more than 55 minutes, then for every 55 minutes slot you will secrete insulin.

Functions of insulin

Insulin is a conserving hormone which is responsible for energy storage and processes of synthesis in our body. Every time you eat insulin is secreted. It takes care of the end products of digestion of foods that you consume. Surprisingly, though you eat dozens of food items, the end products are only three: glucose from carbohydrates, amino acids from proteins and fatty acids from fats. On an average we need energy to the tune of 2000 calories per day. 1gm glucose/ 1 gm protein gives 4 calories and 1 gm fatty acids give 9 calories. The cells of the body can use glucose or fatty acids for energy. The trillions of cells in the body except cells from organ like brain are happy burning fatty acids. Brain cells have preference for glucose. Glucose from the blood can not directly enter the cells as there is a lock on each cell, technically called insulin receptor. For glucose to enter the cells, insulin must open the lock of insulin receptors. Then only cells can get glucose. Brain cells are again exception to this as they can directly take glucose from the blood. The first function of insulin is to allow the entry of glucose in cells. Cells then utilize glucose and perform their functions. If there is some more glucose in blood, it is converted to a substance called glycogen in liver and muscles under the influence of insulin. Generally an adult would have 100gm of glycogen reserve in liver. If there is still more glucose in blood, then

insulin converts this into fatty acids and stores in body as fats! Insulin

converts amino acids into useful proteins and also stores fatty acids as fats in body. Thus it is a conserving hormone responsible for synthesis in the body. Insulin acts a switch to shuffle between use of glucose or fatty acids by the body. If high, body uses glucose and if low, body uses fatty acids as fuel. This is called as day cycle and night cycle in physiology.

Effects of hyperinsulinemia

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Posted by: Ravi Narasimhan <ravi.narasimhan.in@gmail.com>

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Friday, 2 November 2018

[www.keralites.net] Straw Berries

Strawberries prevent heart disease, diabetes

Strawberries, the traditional summer treat, could offer unexpected health benefits of preventing development of heart disease and diabetes, says a study.

University of Warwick scientists have been studying the beneficial effects of strawberries on cardiovascular health, particularly around how they prevent the development of heart disease and diabetes.

Paul Thornalley, professor at the Warwick Medical School, heads the team that discovered extracts from strawberries positively activate a protein in our bodies called 'Nrf2', which is shown to increase antioxidant and other protective activities.

This protein works to decrease blood lipids and cholesterol, the very things which can lead to cardiovascular problems, said a university statement.

Eating strawberries has previously been found to counter post-meal blood glucose and low density lipoprotein, or 'bad' cholesterol and therefore decrease risk of diabetes and heart disease, but this is the first time that strawberry extracts have been proved to actively stimulate proteins that offer us protection against disease.

Thornalley explained: " We've discovered the science behind how strawberries work to increase our in-built defences to keep cells, organs and blood vessels healthy and which can reduce the risk of developing cardiovascular problems such as heart disease and diabetes."

Screening and math modelling techniques developed at Warwick can now take this research further to help identify the best varieties of strawberries, how they are served or processed and how many strawberries should be eaten for optimum health benefit.

Thornalley will be presenting these findings at the 16th biennial meeting for the Society for Free Radical Research International (SFRRI), Imperial College London.

source: http://indiatoday.intoday.in/story/strawberries-prevent-heart-disease-and-diabetes/1/204053.html

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[www.keralites.net] Very Nice Article by Kushwant Singh

Very nice article by Khushwant Singh who passed
away on March 21st 2014 at the age of 99

I've often thought about what it is that makes
people happy—what one has to do in order to
achieve happiness.
First and foremost is good health. If you do not
enjoy good health, you can never be happy. Any
ailment, however trivial, will deduct something
from your happiness.
Second, a healthy bank balance. It need not run
into crores, but it should be enough to provide
for comforts, and there should be something to
spare for recreation—eating out, going to the
movies, travel and holidays in the hills or by the
sea. Shortage of money can be demoralising. Living
on credit or borrowing is demeaning and lowers one
in one's own eyes.
Third, your own home. Rented places can never give
you the comfort or security of a home that is
yours for keeps. If it has garden space, all the
better. Plant your own trees and flowers, see them
grow and blossom, and cultivate a sense of kinship
with them.
Fourth, an understanding companion, be it your
spouse or a friend. If you have too many
misunderstandings, it robs you of your peace of
mind. It is better to be divorced than to be
quarrelling all the time.
Fifth, stop envying those who have done better
than you in life—risen higher, made more money, or
earned more fame. Envy can be corroding; avoid
comparing yourself with others.
Sixth, do not allow people to descend on you for
gup-shup.. By the time you get rid of them, you
will feel exhausted and poisoned by their
gossip-mongering.
Seventh, cultivate a hobby or two that will
fulfill you—gardening, reading, writing, painting,
playing or listening to music. Going to clubs or
parties to get free drinks, or to meet
celebrities, is a criminal waste of time. It's
important to concentrate on something that keeps
you occupied meaningfully.
Eighth, every morning and evening devote 15
minutes to introspection. In the mornings, 10
minutes should be spent in keeping the mind
absolutely still, and five listing the things you
have to do that day. In the evenings, five minutes
should be set aside to keep the mind still and 10
to go over the tasks you had intended to do.
Ninth, don't lose your temper. Try not to be
short-tempered, or vengeful. Even when a friend
has been rude, just move on.
Above all, when the time comes to go, one should
go like a man without any regret or grievance
against anyone. Iqbal said it beautifully in a
couplet in Persian: "You ask me about the signs of
a man of faith? When death comes to him, he has a
smile on his lips."
I don't fear death. What I dread is the day I go
blind or am incapacitated because of old
age—that's what I fear—I'd rather die than live in
that condition. I'm a burden enough on my daughter
Mala and don't want to be an extra burden on her.
All that I hope for is that when death comes to
me, it comes swiftly, without much pain, like
fading away in sound slumber. Till then I'll keep
working and living each day as it comes.
- Khushwant Singh (96) in 2011

M.D.HEGDE MANGALORE

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Thursday, 1 November 2018

[www.keralites.net] Simple Method to Lose Weight and Prevent Diabetes Dr. Jagannath V Dixit MBBS, MD..

Simple Method to Lose Weight and Prevent Diabetes-

Dr. Jagannath V Dixit - MBBS, MD

Professor and Head of Community Medicine Department at Government Medical College, Latur, Maharashtra

Please get latest reports of HbA1C and fasting insulin (not sugar)done and then send reports on whatsapp to only one of the following numbers:

Don't call

Please note that we accept HbA1C by HPLC method and require graph. Insulin by CLIA/ECLIA or CMIA method.

कृपया HbA1C व fasting insulin (शुगर नाही) चे गेल्या सात दिवसातील रिपोर्ट खालील पैकी फक्त एका मोबाइलवर व्हाट्सअप्प द्वारे पाठवा:

फोन करु नका

लक्षात घ्या की HbA1C तपासणी HPLC पद्धतीने करणे व त्याचा ग्राफ सादर करणे आवश्यक आहे.
fasting insulin तपासणी CLIA/ECLIA/CMIA पद्धतीने करणे आवश्यक आहे.